MAPT and Alzheimer disease: However, in addition to patients with AD, increased total tau levels in the CSF of patients with certain other neurological diseases, such as acute stroke, Creutzfeldt-Jakob disease and natalizumab-treated multiple sclerosis (Otto et al., 1997; Hesse et al., 2000; Kapaki et al., 2001; Llorens et al., 2016; Mellergård et al., 2017).