EGR1 and schizophrenia: In this context, a similar dysregulation of EGR1 expression is observed in other neuropsychiatric disorder characterized by functional alterations in PFC activity such as schizophrenia, where Egr1 mRNA levels are also found down-regulated in the dorsolateral prefrontal cortex (Yamada et al., 2007; Kimoto et al., 2014).