In healthy controls, the EBI3 rs428253 polymorphism was associated with the presence of hyperuricemia (Phet = 0.024, Pcod1 = 0.032), the EBI3 rs4740 was associated with decreased risk of central obesity (Phet = 0.035, Pcod2 = 0.038) and with increased risk of high levels of AST > p75 (Padd = 0.046, Pdom = 0.014, Phet = 0.015, and Pcod1 = 0.011), and the EBI3 rs4905 was linked with reduced risk of central obesity (Prec = 0.040, Pcod2 = 0.046) and increased risk of high levels of AST > p75 (Pdom = 0.020, Phet = 0.020, and Pcod1 = 0.016). This evidence concerns the gene EBI3 and hyperuricemia.