In premature CAD patients under different models, the EBI3 rs428253 polymorphism was associated with high levels of ALT > p75 (Padd = 0.006, Pdom = 0.004, Phet = 0.010, and Pcod1 = 0.006) and AST > p75 (Pcod2 = 0.042) and with decreased risk of developing T2DM (Pdom = 0.033, Phet = 0.022, and Pcod1 = 0.022). This evidence concerns the gene EBI3 and coronary artery disorder.