SPR and Bradycardia: We determined the SBP and HR of male Spr−/− mice of 3 weeks to 5 months old, and it revealed that the hypertension and bradycardia of the Spr−/− mice became evident after weaning, at 1 month old, while, there were no significant differences between the SBP and the HR of the wild‐type mice and those of the heterozygous Spr+/− mice (Fig. 1A and B).