Apart from mTOR inhibitors, the negative regulator of the PI3K/Akt pathway AHRI, dual PI3K/mTOR inhibitors PI-103 and NVP-BEZ235, Akt inhibitors and the tumour suppressor gene PTEN may also be used to promote cell death in tumour cells [2, 4]. The gene discussed is AKT1; the disease is neoplasm.