The anti-dsDNA antibodies play critical roles in lupus nephritis; however, elevation of autoantibodies, particularly anti-dsDNA antibodies, has been identified in double-transgenic BALB/c mice expressing both the R4A-gamma2b heavy chain and the anti-apoptotic bcl-2 gene, but the mice did not develop nephritis [34]. The gene discussed is BCL2; the disease is lupus nephritis.