An interesting study by Orechia et al. [130] has shown the syndecan-1 co-expression with VM markers in melanoma patient cell lines having vasculogenic/stem-cell like phenotype; melanoma cells lose their ability to form tubule-like structures in vitro after blocking syndecan-1 activity by the specific human recombinant antibody, OC-46 F2 while the combined therapy using OC-46 F2 and L19-IL2, led to a complete inhibition of tumor growth until day 90 from tumor implantation in 71% of treated mice [130]. Here, IL2 is linked to melanoma.