CDH5 and melanoma: In a recent report our group has shown that the use of PARP inhibitors was effective in preventing melanoma-derived lung metastasis in a murine model and this effect was in part explained by PARP inhibitor’s faculty to counteract VM through down-regulation of VE-cadherin concomitant to the loss of EMT attributes linked to a decreased vimentin expression and Integrin-Linked Kinase/GSK3β axis down-regulation [127].