HMOX2 (heme oxygenase-2), CSTF2 (cleavage stimulation factor, 3′ pre-RNA, subunit 2, 64 kDa), and POLA1 (polymerase (DNA directed), alpha 1) were the three obviously significant related genes, and a marginal significant correlation was found between EFNB2 (ephrin-B2) and prognosis of bladder cancer (Table 3). The gene discussed is POLA1; the disease is urinary bladder carcinoma.