CD4 and tuberculosis: Recently, a multi-country randomized controlled trial based in sub-Saharan Africa found that urine-LAM testing in addition to standard-of-care TB diagnostics was associated with a 17% (95% CI 4–28) relative risk reduction in 8-week all-cause mortality among HIV-infected patients requiring acute medical admission; in those with CD4 counts <50 cells/μL, the implementation of LAM was associated with a 29% (95% CI 10–44) relative risk reduction in 8-week all-cause mortality [30].