Wielscher et al. reported four significant (FDR-corrected p-value < 0.05) CpG sites - cg05979020 (HOXD10), cg05964935 (N/A), cg05769349 (TBX5) and cg10384245 (ADCYAP1) - from their COPD case-control comparison. Here, ADCYAP1 is linked to chronic obstructive pulmonary disease.