2009). The amyloid beta (Aβ) peptides are the major components of senile plaques, which are derived from the altered proteolytic processing of Amyloid Precursor Protein (APP). BACE-1 (β-secretase) is the enzyme which is responsible for the generation of toxic Aβ fragments from APP, thereby it promotes the toxicity in brains of AD (Zhao et al. 2013). This evidence concerns the gene APP and Alzheimer disease.