Although clinically heterogeneous, ranging from dementias such as Alzheimer's disease (AD) or frontotemporal dementia (FTD) to movement disorders such as progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), they are all characterized by the deposition of abnormal tau protein in different regions of the brain [40]. Here, MAPT is linked to frontotemporal dementia.