The processes regulating the secretion of IGFBP3 from corneal epithelial tissue is not known, but in experiments with immortalized human corneal epithelial cells, it was found that high levels of glucose in the culture medium can induce the production of IGFBP3, suggesting that the hyperglycemia in patients may be the cause of the IGFBP3 upregulation. Here, IGFBP3 is linked to Hyperglycemia.