PYY and obesity due to melanocortin 4 receptor deficiency: These findings are aligned with work of others who have shown increased post-prandial triglycerides with MUFA diet,27 upregulation of proinflammatory obesity-linked gene expression by SFA diet25 and SFA-mediated differential expression of ghrelin and peptide YY in favor of increased appetite,28 altogether suggest that SFA may promote MetS in part by alteration of triglycerides/free fatty acids cycling in favor of increased appetite and obesity.