In view of the importance of diabetes for maternal and neonatal health, the objective of the present study was to assess the influence of diabetes on the expression of albumin (ALB), alpha-Fetoprotein (AFP), Hepatic Nuclear Factor-4 alpha (HNF-4α) and miR-122 by liver fetal cells from hyperglycemic and normoglycemic NOD mice at 19, 5 day of gestation. Here, HNF4A is linked to diabetes mellitus.