In adipose tissue, production of IL-6, like TNF-α, is higher in visceral adipose tissue in obesity and metabolic syndrome.31 One of the main actions of IL-6, is control of the liver's production of inflammatory molecules such as C-reactive protein (CRP), whose circulating levels are a risk marker for cardiovascular events. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.