NLRP3 and obesity due to melanocortin 4 receptor deficiency: Moreover, blockage of IL-1β production reduces hyperglycemia and tissue inflammation.36, 37 In a recent study, it was demonstrated that a high content of fatty acids increases the production and secretion of IL-1β, IL-6 and IL-8 via activation of the inflammasomes NLRP3,38 and induces the development of obesity and insulin resistance.