NLRP3 and Insulin resistance: Its relationship with obesity emerges from a recent study, which demostrated that obesity induces the assembly of inflammasome NLRP3 by macrophages in adipose tissue, which mediates insulin resistance and early type 2 diabetes as mentioned before.42 This may be due to the presence of lipid molecule ceramide, which is generated by macrophages from free fatty acids.42 In mice with a free feed normal diet, it was found that increased expression of both NLRP3 and IL-1β in visceral adipose tissue correlates directly with body weight and adiposity compared to mice fed with a low-calorie diet.