IL6 and Insulin resistance: Moreover, the production of IL-6 by adipose tissue could directly affect liver metabolism by inducing secretion of VLDL and hypertriglyceridemia, through the portal venous system.32 Similarly, the action of this cytokine inhibits phosphorylation of the substrate of insulin receptor 1 and 2 (IRS 1 & IRS2) and blocks the synthesis of hepatic glycogen which results in insulin resistance.