CXCL8 and obesity due to melanocortin 4 receptor deficiency: This amplification of cell damage is associated with the production of IL-1β, and activates the expression of more than 30 cytokines and chemokines, including CSF3, CXCL1, CXCL2, CXCL12, MCP-1, IL-8, IP-10, MIP-1α and MCP-4.39 In conclusion, the diverse action of IL-1β promotes the development of obesity and insulin resistance.