There is a strong correlation between the protein content of IL-6 in adipose tissue and circulating levels of CRP.32 In addition, IL-6 plays a central role in the relationship between obesity, inflammation, and coronary heart disease; in fact, intra- abnominal visceral adipose tissue can produce greater amounts of IL-6 than subcutaneous adipose tissue,32 proving that central obesity increases cardiovascular risk in humans. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.