CR3 is a human cell surface receptor, which consist of a differentiation molecule 11b (CD11b) and CD18, and is found on polymorphonuclear leukocytes, NK cells and mononuclear phagocytes like macrophages and microglia cells.56, 57 Recent evidence has shown that primary deficit in microglia such as deficient of complement receptor 3 (CR3) was sufficient to induce some autism-related behavioral and functional connectivity deficits.58 Also, pathological CR3-dependent synaptic pruning might occur during inflammatory neuropathologies such as stroke, trauma and neurodegenerative diseases. Here, CRIPTO3 is linked to neurodegenerative disease.