N-glycans are ligands for galectin 1 and 3 at the cell surface, forming lattices that enhance the residence time of receptors as glucose transporters (GLUT4, GLUT2).74, 75N-glycosylation indirectly affects metabolism by regulating the surface expression of growth factors receptors, which activate signal transduction pathways that regulate cell growth and metabolism.73, 75 Together with previous data,2, 11, 73, 76 we might suggest that hyperglycemia influences localization and organization of surface glycoproteins. The gene discussed is SLC2A2; the disease is Hyperglycemia.