SELE and colonic neoplasm: Expression of glycans decorated by α2-3-linked sialic acid (MAA labeling) found here is in accordance with studies showing α2-3-sialylation to be elevated in metastatic colon cancer cell lines.70 α2-3-sialylated glycans are major components of cancer-associated sialyl Lewis antigens which play an important role in E-selectin-mediated cancer cell adhesion to vascular endothelial cells during the course of hematogenous metastasis.71 Thus, influence of hyperglycemia on expression of sialyl Lewis oligosaccharide by MC38 cells must be verified.