Many authors have reported that several cancer types, including breast, bladder, prostate and colon display higher levels of OGT or O-GlcNAcylation in grade II or III tumors in comparison to grade I cancers indicating an association with malignancy.78 These reports are in agreement with our observation that expression of O-GlcNAcylated proteins in patient tumor tissues is higher when compared with the adjacent normal tissues. The gene discussed is OGT; the disease is cancer.