OGT and Hyperglycemia: Epigenetic regulation of glycosylation is a relatively new emerging concept but with enough studies completed to highlight its importance.86, 87, 88MGAT5B, the coding gene for N-glycan branching enzyme GnT-IX, is regulated by epigenetic mechanism involving chromatin activation by the OGT–TET3 complex.89, 90 In future studies, it would be interesting to investigate the influence of hyperglycemia in histone modifications for the other glycan genes.