Yet, despite a statistically significant difference between such nonstreptococcal Gram-positive infections and other episodes, especially for local levels of IL-17A, interferon-γ, and IL-15, RF-based algorithms were not as powerful in this case as for the above predictions of Gram-negative or streptococcal infections, most likely due to the remaining heterogeneity of the organisms in that patient group (Supplementary Table S6B). This evidence concerns the gene IL15 and streptococcal infection.