ADCY10 and neoplasm: Tumorigenesis is promoted in both thymocytes and the liver by heterozygous or homozygous deletion of Trp53, reflecting the ability of Trp53 loss to tolerize cells to SAC inactivation as well as the role of Trp53 as a potent tumor suppressor (Foijer et al., 2014; Fujiwara et al., 2005; Baker et al., 2009).