MAD2L1 and hepatocellular carcinoma: When we crossed the murine analog of this mutation (Trp53-R246S) into Mad2l1-mutant animals (Alb-Cre::Mad2l1f/f::Trp53R246S mice; [Yin et al., 1998]) we observed early death and extensive HCC (Alb-Cre::Mad2l1f/f::Trp53R246S vs. Alb-Cre:Trp53R246S littermates; p<0.001; compare Figure 2A and E, red lines).