ALB and hepatocellular carcinoma: To determine if HCA actually gives rise to HCC in Alb-Cre::Mad2l1f/f::Trp53f/f and Alb-Cre::Mad2l1f/f::Trp53f/+ animals, gain and loss of chromosomes was profiled by aCGH in HCA, HCC, and unaffected liver (see Materials and methods, NCBI GEO GSE63689 and GSE63100).