Of note, among switch genes we found many well-known cancer-related mRNAs (such as BIRC5, AURKA, RAD51, MBL and EZH2)19, 20, 21, 22, 23 as well as oncogenic miRNAs (such as the miR-200 family, miR-21, miR-203, miR-210, the miR-182/183/96 cluster)24, 25, 26, 27, 28. This evidence concerns the gene EZH2 and cancer.