Finally, CHR element is not only necessary for the repression of gene transcription in G0/G1, but also for the activation of cell cycle genes during G2 and M phases, by a direct binding with MYBL2 (B-MYB) and FOXM39, 62, two pro-oncogenic genes that we have found in the list of cancer-recurrent switch genes. This evidence concerns the gene MYBL2 and cancer.