In our previously work, we demonstrated that ischemic acute kidney injury was ameliorated in renal proximal tubule Bax knockout mice [PT-Bax(−/−)] mice and global Bak knockout [Bak(−/−)] mice, supporting a critical role of Bax/Bak-mediated mitochondrial pathway of apoptosis5. Here, BAK1 is linked to urogenital neoplasm.