TLE6 and hydatidiform mole: In humans, maternal loss of function of some of the genes that encode proteins of the SCMC complex also result in reproductive failure: maternal mutations in PADI6 and TLE6 (PREMBL; OMIM# 616814) cause preimplantation embryonic lethality, while women with KHDC3L mutations experience a recurrent rare specific form of pregnancy loss, recurrent biparental hydatidiform moles (BiHM) (HYDM2; OMIM# 614293)15, 16, 17.