In addition to tumour cells in the circulation, we assessed whether our approach could amplify TRAIL-mediated apoptosis in solid tumour models, where tumour cells are exposed to a variety of physical forces including blood flow from leaky tumour vasculature, interstitial flows between blood and lymphatic circulation as well as interstitial fluid pressures generated within solid tumours10, 46, 47, 48. This evidence concerns the gene TNFSF10 and neoplasm.