TNFSF10 and neoplasm: To overcome resistance, several agents have been combined with TRAIL to sensitize tumour cells to apoptosis, including conventional chemotherapeutics (that is, doxorubicin, cisplatin), proteasome inhibitors, quercetin, BCL2 (B-cell lymphoma 2) inhibitors, IAP (inhibitor of apoptosis protein) antagonists, CD20 antibodies, irradiation, Sorafenib, aspirin, histone deacetylase inhibitors and natural products such as resveratrol and piperlongumine22.