A recent study using cell-specific inducible Cre recombinase (iCre) to knock down soluble guanylate cyclase (sGC) found that nitrergic responses were affected only to a minor extent when the lesion in sGC was directed at ICC and only partially decreased when sGC was knocked down in smooth muscle cells19. The gene discussed is SGCB; the disease is intrahepatic cholangiocarcinoma.