In studies by Baj-Krzyworzeka et al. [74], ectosomes released by pancreatic adenocarcinoma (HPC-4), colorectal adenocarcinoma (DeTa) and lung carcinoma (A549) cell lines increased in vitro secretion of proangiogenic cytokine IL-8 by monocytes. The gene discussed is CXCL8; the disease is lung carcinoma.