The more recent analysis of GBMs by The Cancer Genome Atlas Research Network (TCGA) highlighted the most frequent alterations in GBM genes, including amplification of EGFR and platelet-derived growth factor receptor alpha (PDGFRA); mutation of TP53, phosphatidylinositol-4,5-bisphosphate 3-kinase A (PIK3CA), PTEN, IDH1, RB1, and TERT promoter; and deletions of PTEN, CDKN2A/B, and MGMT, as well as alterations in chromatin remodeling genes. This evidence concerns the gene PIK3CA and glioblastoma.