CD8A and neoplasm: We found that TILs were non-responsive to stimulation, with much lower degranulation (measured by the appearance of CD107 protein on the cell surface), poor cytolytic activity (measured by chromium release assay) and low cytokine production compared to CD8-T cells and NK cells isolated from the non-tumor inflicted pole of the kidney (NILs) or from peripheral blood (PBLs).