CCNE1 and cancer: For the purpose of validation, BIRC5, ECF1, CCNE1 and CDKN2A were searched in Oncomine Research Edition (Rhodes et al., 2004) (https://www.oncomine.org) filtered with the Cancer Type of Liver Cancer. Oncomine is an online platform gathering cancer expression datasets and providing data mining services, which currently includes 715 datasets and 86,733 samples as of Jan 15, 2017 (Rhodes et al., 2004).