The protein expression level of MAT2A is decreased in renal cell carcinoma compared to normal tissues (Wang et al., 2014), while MAT2A is over-expressed in various gastrointestinal cancers, such as gastric cancer, colon cancer and liver cancer (Zhang et al., 2013; Tomasi et al., 2013). The gene discussed is MAT2A; the disease is renal cell carcinoma.