As Fig. 4 shown, LCK, SERBP1, WIPF1, PFKFB3 and RBFOX2 were down-regulated in peripheral blood cells of RA, but those genes were up-regulated in synovial tissues of RA; POU6F1 and CA5A were down-regulated in peripheral blood cells of RA, but they were up-regulated in synovial tissues of RA. This evidence concerns the gene PFKFB3 and rheumatoid arthritis.