While the patterns suggest that there may be differences between autism cases and controls within the ZFP57 and PRRT1 regions, it is important to note that raw methylation values have been plotted, which does not account for sources of variation, and secondly, the direction of effect is only consistent with the direction of effect from Ladd-Acosta et al. for the ZFP57 region (hypermethyion). The gene discussed is PRRT1; the disease is autism.