Given the model of a neurophysiological imbalance leading to heightened neural excitability and the increased prevalence of seizures in FXS patients and fmr1 KO mice, and with due consideration of the challenges integrating knowledge from intracranial recordings and clinical data, it is noteworthy that few EEG studies of resting brain function have yet been conducted with FXS patients. This evidence concerns the gene FMR1 and fragile X syndrome.