Previous studies assessing the mitochondrial response to EET reported either no change in total mitochondrial volume density or a down-regulation in expression of genes involved in mitochondrial biogenesis (PGC-1α) and function (cytochrome oxidase subunit 4) in healthy young, elderly, and patients with coronary artery disease (LaStayo et al., 2000; Steiner et al., 2004; Zoll et al., 2006; Mueller et al., 2011). Here, PPARGC1A is linked to coronary artery disorder.