The production of a number of metabolites such as beta endorphins, prostaglandins and hypoxia-inducible factor-1 α (HIF 1 α) are postulated to result from ischemia induced by full or partial restriction of the brachial artery during IHG exercises (Stiller-Moldovan et al., 2012; Wong and Wright, 2014; Wong et al., 2015). Here, POMC is linked to ischemia.