Quantitative RT-PCR analysis of 5-LOX specific mRNA revealed a significant increase in synovial tissues of RA patients, while immunofluorescence confocal microscopy showed a significant increase of 5-LOX-IR cells in synovial tissues of JT, OA, and RA patients compared to controls which was more prominent in RA patients (P < 0.05, Figure 1). The gene discussed is ALOX5; the disease is rheumatoid arthritis.