The discovery of recombinant form of IAP raises a hope that clinical studies in the future can shed more light on the intriguing opportunity of a therapeutic strategy concerning the efficacy of this enzyme in treatment of human diseases especially to prevent dysbiosis and intestinal and systemic inflammation frequently associated with lower GI tract disorders such as IBD, IBS, and Clostridium difficile infection. Here, ALPI is linked to clostridium difficile infection.