Our study provides evidence that leads to the following conclusions: (i) dyslipidemia seemed to be the primary disease associated mainly with increase of IL10 and IFNA and decrease of IFNG, IP10, IRF1, JAK1, and STAT3 gene expression; (ii) T2D and CP also participate in gene expression, since glucose and periodontal parameters significantly correlated with the mRNA levels of the investigated immune genes. This evidence concerns the gene IRF1 and metabolic syndrome.