Our study provides evidence that leads to the following conclusions: (i) dyslipidemia seemed to be the primary disease associated mainly with increase of IL10 and IFNA and decrease of IFNG, IP10, IRF1, JAK1, and STAT3 gene expression; (ii) T2D and CP also participate in gene expression, since glucose and periodontal parameters significantly correlated with the mRNA levels of the investigated immune genes. The gene discussed is STAT3; the disease is metabolic syndrome.