Univariate analysis indicates that TNM stage, adjuvant chemotherapy, Rab1B and MMP9 proteins are significant predictors for OS and PFS of CRC patients (All P < 0.05, Table 3), and Tumor depth is a marginally significant predictor for OS and PFS (P =0.065 and P =0.059, respectively, Table 3). This evidence concerns the gene MMP9 and neoplasm.