MMP9 and colorectal carcinoma: Compared with TNM staging system, Rab1B/MMP9 combined risk score has some better predictive accuracy for OS (ROC area: 0.76 vs. 0.71, Fig. S1A) and PFS (ROC area: 0.73 vs. 0.69, Fig. S1B) of CRC patients though there is no statistically significant difference between the two ROC areas.