Multivariate Cox regression analysis further demons-trates that Rab1B protein is an independent risk predictor for OS (HR: 3.605, 95% CI: 1.481-8.775, P = 0.005) and PFS (HR: 3.394, 95% CI: 1.579-7.297, P = 0.002) of CRC patients (Table 3), and MMP9 protein is a marginally significant independent unfavorable predictor for OS and PFS in CRC patients (Table 3). Here, MMP9 is linked to colorectal carcinoma.