ICAM1 and stroke disorder: However, these changes are different between AIS and moderate to severe stroke; all four EMP phenotypes (CD105+/CD41a−/CD45− EMPs, CD105+/CD144+ EMPs, CD105+/PS+/CD41a− EMPs and CD105+/CD54+/CD45− EMPs) studied were shown to be elevated in the subgroup of moderate to severe stroke patients compared with controls 5.