RYR2 and heart failure: Multiple studies have demonstrated that dantrolene reduces RyR2‐mediated Ca2+ leak, decreasing the incidence and duration of Ca2+ sparks in cultures of cardiomyocytes modelling both CPVT26 and cardiac failure.27, 28 Dantrolene may enhance the interactions between the N‐terminal and the central domain of the RyR2 molecule.