RYR2 and catecholaminergic polymorphic ventricular tachycardia: Previous studies had reported that: (i) The RyR2‐P2328S modification, associated with human catecholaminergic polymorphic ventricular tachycardia (CPVT) resulted in increased arrhythmic tendency and increased RyR2‐mediated Ca2+ release in murine ventricles.30 (ii) This was accompanied by reductions in the CVs of both ventricular7 and atrial APs that could potentially create arrhythmic substrates.8, 9 (iii) The altered Ca2+ homeostasis also appeared to modify the Na+ current with consequences for CV.