EGFR and non-small cell lung carcinoma: NVP-AUY-922, a non-geldanamycin heat shock protein 90 (HSP90) inhibitor, can potently downregulate EGFR and c-MET, and can overcome c-MET-mediated resistance in an EGFR TKI-resistant clone of NSCLC cell line HCC827 [8].