An example of the importance of the biomechanical strength conferred by MBs is evident in ciliary zonules, where an abundance of fibrillin-1 microfibrils is responsible for holding the lens in dynamic suspension, with a loss of this structural anchorage in Marfan syndrome leading to ectopia lentis (Ashworth et al., 2000). Here, FBN1 is linked to Marfan syndrome.