NPPB and hydrops fetalis: Among 224 patients with acute MI and clinical HF from the OPTIMAAL study, higher copeptin levels outperformed BNP and NT-proBNP in predicting major cardiovascular (CV) events during 33 months of follow-up with a hazard ratio (HR) of 1.35 (95% confidence interval [CI] 1.05–1.72) [31].