Somewhat in contrast to the lack of prognostic value of GDF-15 in invasively treated patients in FRISC-II, the addition of levels of GDF-15, NT-proBNP and the extent of coronary artery disease to clinical variables in a study of 5174 revascularized patients with NSTE-ACS from the PLATO trial independently improved prognostication of CV death or spontaneous MI (c-statistics 0.69 for the full model vs 0.65 for the clinical model) [61]. This evidence concerns the gene GDF15 and myocardial infarction.