This positive signal has provided the foundations for a clinical trial in Australia: A Randomised Phase II study of veliparib and RT with adjuvant TMZ and veliparib versus standard RT and TMZ followed by TMZ in patients with newly diagnosed GBM with unmethylated O(6)-methylguanine-DNA methyltransferase (The VERTU study; ANZCTR: U1111-1167-6365). The gene discussed is MGMT; the disease is glioblastoma.