Interestingly, large quantities of neutrophil cytosol proteins, such as myeloperoxidase, elastase, MMP-8 and defensins, were detected by a proteomic study in necrotic tissue of caseous granulomas and cavitary lesions, but not in solid granulomas, obtained from patients with severe pulmonary tuberculosis that needed surgical treatment [23]. This evidence concerns the gene MMP8 and Granuloma.