SYK and breast carcinoma: This discrepancy could be explained by the distinct cell models (breast cancer versus colorectal cancer cells) and by the fact that Leroy and colleagues [52] analyzed global Syk phosphorylation rather than specific phosphorylation on the Tyr525/526 residues, which are located in the activation loop of the Syk kinase domain and are more relevant to detect changes in Syk catalytic activity [54].