Although Pten+/−/Park2+/− and Pten+/−/Park2−/− mice showed a similar spectrum of tumors like the ones detected in Pten+/−/Park2+/+ mice, they were significantly more tumor prone and exhibited features reminiscent of mice with a hypomorphic and a knockout Pten allele (Figure 7A). This evidence concerns the gene PRKN and neoplasm.