Phosphatase PP2A is a confirmed tumor suppressor (Sangodkar et al., 2016), and it was reported to dephosphorylate both MEK and ERK (Bae and Ceryak, 2009; Letourneux et al., 2006; Millward et al., 1999; Tay et al., 2012). The gene discussed is PTPA; the disease is neoplasm.