We then selected one of these six PRPF6 SNPs (rs8126213) and investigated its association with lung cancer risk in two additional lung-cancer GWASs of Caucasian origin, Harvard Lung Cancer Study (984 cases and 970 controls) and Icelandic Lung Cancer Study (deCODE from the ILCCO) (1,319 cases and 26,380 controls). The gene discussed is PRPF6; the disease is lung cancer.