Abnormal expression of PRPF6 alters the constitutive and alternative splicing of a discrete number of genes, including an oncogenic isoform of the ZAK kinase33 that activates several cancer (including lung cancer)-related signaling pathways, such as those of NF-kB, Wnt/b catenin, AP1, ERK and JNK34, 35. The gene discussed is PRPF6; the disease is lung cancer.