Using RNA-seq data for 20 FLC tumors from Honeyman et al. 17 we confirmed that 14 out of the 16 genes (except CREB3L1 and ITPRIP) are indeed significantly elevated in FLC relative to HCC and CCA (Supplementary Fig. S7). This evidence concerns the gene CREB3L1 and fibrolamellar hepatocellular carcinoma.