Yet, among NSAIDs, some might increase the production of interleukin-1 (IL-1β) or tumor necrosis factor (TNF-α) like indomethacin (nonselective inhibitor of COX-1 and COX-2) and these effects have been considered important in the development of GI (gastrointestinal) ulcers and asthma attributed to these drugs. This evidence concerns the gene IL1B and asthma.